Furthermore, early surgery can significantly reduce mortality and hospital stay, which is conducive to patient recovery. It is unnecessary to delay surgery to restore platelet function when patients with hip fractures receive antiplatelet therapy. However, early surgery appeared to decrease the length of hospitalization (WMD = − 6.05 95% CI, − 7.06 to − 5.04 p < 0.001) and mortality (OR = 0.43 95% CI, 0.23 to 0.79 p = 0.006). Early surgery for hip fracture patients on antiplatelet therapy was associated with a greater decrease in hemoglobin compared to delayed surgery (WMD = 0.75 95% CI, 0.50 to 1.00 p < 0.001). Early surgery was associated with an increased transfusion rate in the antiplatelet group compared to the non-antiplatelet group (OR = 1.21 95% CI, 1.01 to 1.44 p = 0.03). Twenty-four studies with 5423 participants were ultimately included in our analysis. In total, 2328 initial articles were identified. ![]() MethodsĬomputerized databases for studies published from the inception date to January 2020, including the Cochrane Library, PubMed (Medline), EMBASE, Web of Science TM, ClinicalTrials, ClinicalKey, and Google Scholar, were searched using the keywords “Hip AND Fracture”, “Antiplatelet”, “Antithrombocyte”, “Platelet aggregation inhibitors”, “Aspirin”, “Plavix”, and “Clopidogrel”. However, determining the timing for surgery has been controversial for patients who develop hip fractures while on antiplatelet treatment. Hip fractures are common and account for a large proportion of orthopedic surgical admissions in elderly patients.
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